#summary Laterodorsal Tegmental Nucleus
@@[Home] -> [BiologicalLifeResearch] -> [BrainAreaLMC] -> [BrainRegionLMC_HT_TG_LDT]
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This page covers biological details of component Laterodorsal Tegmental Nucleus.
Region is part of aHuman target integrated biological model.
* *Top-down path to region*: Hindbrain Metencephalon -> [BrainCenterHT_TG Pontine Tegmental Nuclei] (HT.TG) -> [BrainRegionLMC_HT_TG_LDT Laterodorsal Tegmental Nucleus] (LMC.HT.TG.LDT) (see [OverallMindMaps Mind Maps])
* *Type*: nucleus
* *Quality*: L0
* *Brain area*: [BrainAreaLMC Lower Brain - Modulatory Contol Area] (LMC)
* *Area circuit*: Acetylcholine - PNS Actions and CNS plasticity, arousal and reward (ACH)
* *Role*: processor.autonomic
* *Function*: Modulating sustained attention or in mediating alerting responses
* *Notes to function*:
* sleep, waking, motor function, learning and reward
(generated)
= Components =
(generated)
*Component items*:
* *Lateral Tegmental Nucleus*
* *Dorsal Tegmental Nucleus* (*LMC.HT.TG.DTG*): accurate landmark navigation
* *Dorsal Tegmental Nucleus Pars Dorsalis*
* *Dorsal Tegmental Nucleus Pars Ventralis*
= Connectivity =
(generated)
http://ahuman.org/svn/ahwiki/images/dot/LMC.HT.TG.LDT.dot.png
*Inbound Region Connections:*
|| *Source Area* || *Source Region* || *Source Name* || *Type* || *Role* || *Reference* ||
|| [BrainAreaFAM FAM] || [BrainRegionFAM_FD_LHB_MED FAM.FD.LHB.MED] || Lateral Habenula Medial Part || excitatory-glu || uncertain ||[http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> DTG)] ||
|| [BrainAreaFEC FEC] || [BrainRegionFEC_HT_TG_IPD FEC.HT.TG.IPD] || Interpeduncular Nucleus || modulatory-ach || uncertain ||[http://www.scholarpedia.org/article/Head_direction_cells Head Direction Cell Circuit (IPD -> DTN)] ||
|| || [BrainRegionFEC_HT_TG_RMTG FEC.HT.TG.RMTG] || Rostromedial Tegmental Nucleus || inhibitory-gaba || uncertain ||(unknown reference) ||
|| [BrainAreaFMM FMM] || [BrainRegionFMM_FD_MB_LMB FMM.FD.MB.LMB] || Lateral Mammillary Nucleus || excitatory-glu || uncertain ||[http://www.scholarpedia.org/article/Head_direction_cells Head Direction Cell Circuit (LMB -> DTN)] ||
|| [BrainAreaLAC LAC] || [BrainRegionLAC_FD_HT_VLPO LAC.FD.HT.VLPO] || Ventrolateral Preoptic Nucleus || excitatory-glu || uncertain ||[http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (VLPO -> LDTg)] ||
|| [BrainAreaLRC LRC] || [BrainRegionLRC_HL_NPH LRC.HL.NPH] || Prepositus Nucleus || excitatory-glu || uncertain ||(unknown reference) ||
|| [BrainAreaNSA NSA] || [BrainRegionNSA_FD_TH_SG NSA.FD.TH.SG] || Suprageniculate Nucleus of Thalamus || excitatory-glu || uncertain ||(unknown reference) ||
*Outbound Region Connections:*
|| *Target Area* || *Target Region* || *Target Name* || *Type* || *Role* || *Reference* ||
|| [BrainAreaFEC FEC] || [BrainRegionFEC_HT_TG_IPD FEC.HT.TG.IPD] || Interpeduncular Nucleus || modulatory-ach || uncertain || (unknown reference) ||
|| [BrainAreaFMM FMM] || [BrainRegionFMM_FD_MB_LMB FMM.FD.MB.LMB] || Lateral Mammillary Nucleus || modulatory-ach || uncertain || [http://ahuman.org/svn/ahengine/research/articles/2009-Hippocampus-Thesis.pdf Hippocampal Formation (DTN -> LMam)] ||
|| [BrainAreaLAC LAC] || [BrainRegionLAC_HL_SAL_ISL LAC.HL.SAL.ISL] || Inferior Salivatory Nucleus || modulatory-ach || uncertain || (unknown reference) ||
|| || [BrainRegionLAC_HL_SAL_SSL LAC.HL.SAL.SSL] || Superior Salivatory Nucleus || modulatory-ach || uncertain || (unknown reference) ||
|| [BrainAreaLRC LRC] || [BrainRegionLRC_HL_NPH LRC.HL.NPH] || Prepositus Nucleus || modulatory-ach || uncertain || [http://www.scholarpedia.org/article/Head_direction_cells Head Direction Cell Circuit (DTN -> NPRP)] ||
|| [BrainAreaNSA NSA] || [BrainRegionNSA_FD_TH_SG NSA.FD.TH.SG] || Suprageniculate Nucleus of Thalamus || modulatory-ach || uncertain || [http://www.scholarpedia.org/article/Head_direction_cells Head Direction Cell Circuit (DTN -> SUPGEN)] ||
= Thirdparty Circuits =
(generated)
* [http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/brain/HF.jpg Hippocampal Formation] - see [article:2009-Hippocampus-Thesis.pdf Reference] (CT.HIPPOCAMPAL-FORMATION)
ATN=Anterior Nucleus of Thalamus,FD.TH.AN (see [BrainCenterFD_TH_CR Cognitive Thalamus])
CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see [BrainCenterFMM_FT_HF Hippocampal Formation])
CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see [BrainCenterFMM_FT_HF Hippocampal Formation])
DG=[BrainRegionFMM_FT_HC_DG Dentate Gyrus,FMM.FT.HC.DG]
DTN=[BrainRegionLMC_HT_TG_LDT Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT]
EC=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex])
LDN=[BrainRegionFMM_FD_TH_LD Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD]
LMam=[BrainRegionFMM_FD_MB_LMB Lateral Mammillary Nucleus,FMM.FD.MB.LMB]
PoS=[BrainRegionFMM_NC_PH_POS Postsubiculum,FMM.NC.PH.POS]
Rsp=[BrainRegionNCP_NC_MPL_RSC Retrosplenial Cortex,NCP.NC.MPL.RSC]
Sub=Subiculum,FMM.FT.HF.SUB (see [BrainCenterFMM_FT_HF Hippocampal Formation])
* [http://www.scholarpedia.org/w/images/6/63/Taube_Figure_5a.png Head Direction Cell Circuit] - see [http://www.scholarpedia.org/article/Head_direction_cells Reference] (CT.HEAD-DIRECTION)
AD=[BrainRegionFMM_FD_TH_AD Anterodorsal Nucleus,FMM.FD.TH.AD]
DTN=[BrainRegionLMC_HT_TG_LDT Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG]
EC=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex])
HC=Hippocampus,FMM.FT.HC (see [BrainCenterFMM_FT_HF Hippocampal Formation])
IPD=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD]
LD=[BrainRegionFMM_FD_TH_LD Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD]
LHAB=[BrainCenterFAM_FD_HB Habenula,FAM.FD.HB]
LMB=[BrainRegionFMM_FD_MB_LMB Lateral Mammillary Nucleus,FMM.FD.MB.LMB]
MVSN=[BrainRegionLPC_HT_MVBN Medial Vestibular Nucleus,LPC.HT.MVBN]
NPRP=[BrainRegionLRC_HL_NPH Prepositus Nucleus,LRC.HL.NPH]
PC=Parietal Lobe,NC.LOBE.PAR
PRHC=[BrainRegionFMM_NC_PH_POR Postrhinal Cortex,FMM.NC.PH.POR]
PSUB=[BrainRegionFMM_NC_PH_POS Postsubiculum,FMM.NC.PH.POS]
RSP=[BrainRegionNCP_NC_MPL_RSC Retrosplenial Cortex,NCP.NC.MPL.RSC]
SUPGEN=[BrainRegionNSA_FD_TH_SG Suprageniculate Nucleus of Thalamus,NSA.FD.TH.SG]
VC=[BrainCenterNC_LOBE_OCC Occipital Lobe,NC.LOBE.OCC]
* [http://www.frontiersin.org/files/Articles/70852/fnhum-07-00826-HTML/image_m/fnhum-07-00826-g002.jpg Regulation of the rapid eye movement (REM) sleep by habenular projection] - see [http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full Reference] (CF.REM-HB)
DBB=[BrainRegionFAM_FT_SEP_DBB Diagonal Band of Broca,FAM.FT.SEP.DBB]
DTG=[BrainRegionLMC_HT_TG_LDT Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG]
EPN=[BrainRegionFAM_FT_EPF Endopiriform Nucleus,FAM.FT.EPF]
GPi=Globus Pallidus Internal,FEC.FT.GPI (see [BrainCenterFEC_FT_BG Basal Ganglia])
LHT=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN]
LHbL=[BrainRegionFAM_FD_LHB_LT Lateral Habenula Lateral Part,FAM.FD.LHB.LT]
LHbM=[BrainRegionFAM_FD_LHB_MED Lateral Habenula Medial Part,FAM.FD.LHB.MED]
NI=[BrainRegionFAM_HT_TG_NI Incertus Nucleus,FAM.HT.TG.NI]
RMTg=[BrainRegionFEC_HT_TG_RMTG Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG]
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see [BrainCenterHL_RF Medullary Reticular Formation])
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see [BrainCenterFEC_FT_BG Basal Ganglia])
VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA]
VTG=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTG]
* [http://www.nature.com/nrn/journal/v5/n1/images/nrn1299-f2.jpg Mammillary bodies: two memory systems in one] - see [http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F2.html Reference] (CT.MB-MEMORY)
ADTH=[BrainRegionFMM_FD_TH_AD Anterodorsal Nucleus,FMM.FD.TH.AD]
AMTH=[BrainRegionNCP_FD_TH_AM Anteromedial Nucleus,NCP.FD.TH.AM]
AVTH=[BrainRegionFMM_FD_TH_AV Anteroventral Nucleus,FMM.FD.TH.AV]
DTN=[BrainRegionLMC_HT_TG_LDT Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT]
LMB=[BrainRegionFMM_FD_MB_LMB Lateral Mammillary Nucleus,FMM.FD.MB.LMB]
MMB=[BrainRegionFMM_FD_MB_MMB Medial Mammillary Nucleus,FMM.FD.MB.MMB]
MedialEC=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex])
PAS=[BrainRegionFMM_NC_PH_PAS Parasubiculum,FMM.NC.PH.PAS]
POS=[BrainRegionFMM_NC_PH_POS Postsubiculum,FMM.NC.PH.POS]
PRS=[BrainRegionFMM_NC_PH_PRS Presubiculum,FMM.NC.PH.PRS]
SEP=[BrainCenterFAM_FT_SEP Septal Nuclei,FAM.FT.SEP]
SUB=Subiculum,FMM.FT.HF.SUB (see [BrainCenterFMM_FT_HF Hippocampal Formation])
SupraMM=[BrainRegionLAC_FD_HT_SUM Supramammillary Nucleus,LAC.FD.HT.SUM]
TuberoMM=Lateral Tuberal Nuclei,LAC.FD.HT.LTUB (see [BrainCenterFD_HT Hypothalamus])
VTN=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA]
* [http://www.nature.com/neuro/journal/v5/n10/images/nn913-F1.jpg Simplified NREM sleep-promoting pathway] - see [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Reference] (CL.TBM-PO)
LC=[BrainRegionLMC_HT_LC Locus Coeruleus,LMC.HT.LC]
LDTg=[BrainRegionLMC_HT_TG_LDT Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT]
TMN=[BrainRegionLAC_FD_HT_TBM Tuberomammillary Nucleus,LAC.FD.HT.TBM]
VLPO=[BrainRegionLAC_FD_HT_VLPO Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO]
= References =
(generated)
* article:2009-Hippocampus-Thesis.pdf
* http://www.scholarpedia.org/article/Head_direction_cells
* http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full
* http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F2.html
* http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html