#summary Ventrolateral Preoptic Nucleus
@@[Home] -> [BiologicalLifeResearch] -> [BrainAreaLAC] -> [BrainRegionLAC_FD_HT_VLPO]
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This page covers biological details of component Ventrolateral Preoptic Nucleus.
Region is part of aHuman target integrated biological model.
* *Top-down path to region*: Forebrain Diencephalon -> [BrainCenterFD_HT Hypothalamus] (FD.HT) -> Anterior Hypothalamus Area (LAC.FD.HT.AHT) -> Chiasmatic Area (LAC.FD.HT.CHS) -> Preoptic Nucleus (LAC.FD.HT.PO) -> [BrainRegionLAC_FD_HT_VLPO Ventrolateral Preoptic Nucleus] (LAC.FD.HT.VLPO) (see [OverallMindMaps Mind Maps])
* *Type*: nucleus
* *Quality*: L0
* *Brain area*: [BrainAreaLAC Lower Brain - Autonomous Control Area] (LAC)
* *Area circuit*: Autonomic Thermoregulation (LAT)
* *Role*: processor.autonomic
* *Function*: mediates non-REM sleep onset
* *Notes to function*:
* lesions in VLPO result in insomnia
(generated)
= Components =
(generated)
* no child items defined
= Connectivity =
(generated)
http://ahuman.org/svn/ahwiki/images/dot/LAC.FD.HT.VLPO.dot.png
*Inbound Region Connections:*
|| *Source Area* || *Source Region* || *Source Name* || *Type* || *Role* || *Reference* ||
|| [BrainAreaFAM FAM] || [BrainRegionFAM_FT_AM_MEA FAM.FT.AM.MEA] || Medial Anterior Amygdaloid Nucleus || excitatory-glu || uncertain ||[http://www.pnas.org/content/107/40/17071/F1.expansion.html Role for serotonin in moral behavior (AMY -> HYP, abstract)] ||
|| || [BrainRegionFAM_FT_SEP_LT FAM.FT.SEP.LT] || Lateral Septal Nucleus || inhibitory-gaba || uncertain ||[http://www.thebrainlabs.com Cingulate Gyrus (SEP -> HT, abstract)] ||
|| [BrainAreaFEC FEC] || [BrainRegionFEC_HT_TG_RMTG FEC.HT.TG.RMTG] || Rostromedial Tegmental Nucleus || inhibitory-gaba || uncertain ||(unknown reference) ||
|| [BrainAreaLAC LAC] || [BrainRegionLAC_FD_HT_DM LAC.FD.HT.DM] || Dorsomedial Hypothalamic Nucleus || excitatory-glu || uncertain ||[http://www.dana.org/Publications/ReportDetails.aspx?id=44217 Eating and sleeping to survive (DMH -> VLPO)] ||
|| || [BrainRegionLAC_FD_HT_SCN LAC.FD.HT.SCN] || Suprachiasmatic Nucleus || excitatory-glu || uncertain ||(unknown reference) ||
|| || [BrainRegionLAC_FD_HT_TBM LAC.FD.HT.TBM] || Tuberomammillary Nucleus || modulatory-hist || modulator ||[http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (TMN -> VLPO)] ||
|| || [BrainRegionLAC_FD_HT_VM LAC.FD.HT.VM] || Ventromedial Hypothalamic Nucleus || excitatory-glu || uncertain ||(unknown reference) ||
|| [BrainAreaLMC LMC] || [BrainRegionLMC_HT_LC LMC.HT.LC] || Locus Coeruleus || modulatory-ne || uncertain ||[http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (LC -> VLPO)] ||
|| [BrainAreaNSA NSA] || [BrainRegionNSA_NC_PH_PRP NSA.NC.PH.PRP] || Prepyriform Cortex || excitatory-glu || uncertain ||(unknown reference) ||
*Outbound Region Connections:*
|| *Target Area* || *Target Region* || *Target Name* || *Type* || *Role* || *Reference* ||
|| [BrainAreaFAM FAM] || [BrainRegionFAM_FD_LHB_LT FAM.FD.LHB.LT] || Lateral Habenula Lateral Part || excitatory-glu || uncertain || [http://www.scholarpedia.org/article/Habenula Habenula Connections (LPO -> LHb, abstract)] ||
|| || [BrainRegionFAM_FD_LHB_MED FAM.FD.LHB.MED] || Lateral Habenula Medial Part || excitatory-glu || uncertain || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM)] ||
|| [BrainAreaLAC LAC] || [BrainRegionLAC_FD_HT_SUM LAC.FD.HT.SUM] || Supramammillary Nucleus || excitatory-glu || uncertain || (unknown reference) ||
|| [BrainAreaLMC LMC] || [BrainRegionLMC_HT_TG_LDT LMC.HT.TG.LDT] || Laterodorsal Tegmental Nucleus || excitatory-glu || uncertain || [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (VLPO -> LDTg)] ||
= Thirdparty Circuits =
(generated)
* [http://www.nature.com/neuro/journal/v5/n10/images/nn913-F1.jpg Simplified NREM sleep-promoting pathway] - see [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Reference] (CL.TBM-PO)
LC=[BrainRegionLMC_HT_LC Locus Coeruleus,LMC.HT.LC]
LDTg=[BrainRegionLMC_HT_TG_LDT Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT]
TMN=[BrainRegionLAC_FD_HT_TBM Tuberomammillary Nucleus,LAC.FD.HT.TBM]
VLPO=[BrainRegionLAC_FD_HT_VLPO Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO]
* [http://www.nature.com/neuro/journal/v17/n9/images/nn.3779-F2.jpg Both LHb and MHb control the dopaminergic and serotonergic systems] - see [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Reference] (CF.HB-DA5HT)
DBB=[BrainRegionFAM_FT_SEP_DBB Diagonal Band of Broca,FAM.FT.SEP.DBB]
DRN=[BrainRegionLMC_MM_RP_DRN Dorsal Raphe Nucleus,LMC.MM.RP.DRN]
GPb=Dorsal Pallidum,FEC.FT.DP (see [BrainCenterFEC_FT_BG Basal Ganglia])
IPN=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD]
LHA=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN]
LHbL=[BrainRegionFAM_FD_LHB_LT Lateral Habenula Lateral Part,FAM.FD.LHB.LT]
LHbM=[BrainRegionFAM_FD_LHB_MED Lateral Habenula Medial Part,FAM.FD.LHB.MED]
LPO=[BrainRegionLAC_FD_HT_VLPO Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO]
LS=[BrainRegionFAM_FT_SEP_LT Lateral Septal Nucleus,FAM.FT.SEP.LT]
MHb=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB]
MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see [BrainCenterHL_RF Medullary Reticular Formation])
MS=[BrainRegionFAM_FT_SEP_MED Medial Septal Nucleus,FAM.FT.SEP.MED]
PS=Posterior Septal Group,FAM.FT.SEP.PG (see [BrainCenterFAM_FT_SEP Septal Nuclei])
RMTg=[BrainRegionFEC_HT_TG_RMTG Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG]
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see [BrainCenterFEC_FT_BG Basal Ganglia])
VP=Ventral Pallidum,FEC.FT.VP (see [BrainCenterFEC_FT_BG Basal Ganglia])
VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA]
* [http://www.scholarpedia.org/w/images/thumb/2/2d/Hb-connections-small.jpg/800px-Hb-connections-small.jpg Habenula Connections] - see [http://www.scholarpedia.org/article/Habenula Reference] (CF.HB-CONNECTIONS)
CPu=Striatum,FEC.FT.ST (see [BrainCenterFEC_FT_BG Basal Ganglia])
DBB=[BrainRegionFAM_FT_SEP_DBB Diagonal Band of Broca,FAM.FT.SEP.DBB]
DR=[BrainRegionLMC_MM_RP_DRN Dorsal Raphe Nucleus,LMC.MM.RP.DRN]
GPi=Globus Pallidus Internal,FEC.FT.GPI (see [BrainCenterFEC_FT_BG Basal Ganglia])
IP=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD]
LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (see [BrainCenterFD_HT Hypothalamus])
LHb=Lateral Habenula,FAM.FD.LHB (see [BrainCenterFAM_FD_HB Habenula])
LPO=[BrainRegionLAC_FD_HT_VLPO Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO]
MHb=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB]
MR=[BrainRegionLMC_MM_RP_SUC Superior Central Raphe Nucleus,LMC.MM.RP.SUC]
PB=[BrainRegionTARGET_TEA_ENDOCRINE Endocrine Glands,TARGET.TEA.ENDOCRINE]
S=[BrainCenterFAM_FT_SEP Septal Nuclei,FAM.FT.SEP]
SNc=[BrainRegionFEC_FT_SNC_LT Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT]
VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA]
* [http://www.dana.org/uploadedImages/Images/Content_Images/SenBodyFunc2_PR2007_cont.jpg Eating and sleeping to survive] - see [http://www.dana.org/Publications/ReportDetails.aspx?id=44217 Reference] (CP.DMH-CYCLES)
ARC=[BrainRegionLAC_FD_HT_AR Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR]
DMH=[BrainRegionLAC_FD_HT_DM Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM]
LHA=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN]
MPO=[BrainRegionLAC_FD_HT_MPO Median Preoptic Nucleus,LAC.FD.HT.MPO]
PVH=[BrainRegionLAC_FD_HT_PV Paraventricular Nucleus,LAC.FD.HT.PV]
SCN=[BrainRegionLAC_FD_HT_SCN Suprachiasmatic Nucleus,LAC.FD.HT.SCN]
VLPO=[BrainRegionLAC_FD_HT_VLPO Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO]
VMH=[BrainRegionLAC_FD_HT_VM Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM]
= References =
(generated)
* http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html
* http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html
* http://www.scholarpedia.org/article/Habenula
* http://www.dana.org/Publications/ReportDetails.aspx?id=44217