#summary Lateral Entorhinal Cortex @@[Home] -> [BiologicalLifeResearch] -> [BrainAreaFMM] -> [BrainRegionFMM_NC_PH_LEC] ---- This page covers biological details of component Lateral Entorhinal Cortex. Region is part of aHuman target integrated biological model. * *Top-down path to region*: Cerebral Cortex -> Parahippocampal Lobe (NC.LOBE.PH) -> Anterior Parahippocampal Gyrus (FMM.NC.PHA) -> [BrainCenterNC_PHA_RH Rhinal Cortex] (NC.PHA.RH) -> Entorhinal Cortex (FMM.NC.PH.ET) -> [BrainRegionFMM_NC_PH_LEC Lateral Entorhinal Cortex] (FMM.NC.PH.LEC) (see [OverallMindMaps Mind Maps]) * *Type*: cortex * *Quality*: L0 * *Brain area*: [BrainAreaFMM Forebrain - Memory Management Area] (FMM) * *Area circuit*: Emotional Sensory Input to Hippocampus (MMASENSE) * *Brodmann ID*: 28 * *Role*: processor.memory.complex * *Function*: Memory consolidation, emotional aspects * *Notes to function*: * non-spatial input to HC * process information about individual items and locations based on a local frame of reference, primarily using external sensory input * it provides the hippocampus with information about content of experience (generated) = Components = (generated) * no child items defined = Connectivity = (generated) http://ahuman.org/svn/ahwiki/images/dot/FMM.NC.PH.LEC.dot.png *Inbound Region Connections:* || *Source Area* || *Source Region* || *Source Name* || *Type* || *Role* || *Reference* || || [BrainAreaFAM FAM] || [BrainRegionFAM_FD_TH_PT FAM.FD.TH.PT] || Paratenial Nucleus of Thalamus || excitatory-glu || uncertain ||[http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)] || || || [BrainRegionFAM_FT_AM_BP FAM.FT.AM.BP] || Parvicellular Basal Amygdaloid Nucleus || excitatory-glu || uncertain ||[http://highered.mcgraw-hill.com/sites/dl/free/0071402357/156721/figure350_1.html Principal Connections of Hippocampus (AM -> EC, abstract)] || || [BrainAreaFMM FMM] || [BrainRegionFMM_FT_HF_SUBD FMM.FT.HF.SUBD] || Distal Subiculum || excitatory-glu || uncertain ||[http://learnmem.cshlp.org/content/14/11/714/F1.expansion Attractor Network in Hippocampus (SUB -> EC, abstract)] || || || [BrainRegionFMM_NC_PH_PER FMM.NC.PH.PER] || Perirhinal Cortex || feedforward-glu || uncertain ||[http://www.scholarpedia.org/article/Inferior_temporal_cortex Visual Path to Hippocampus (PRPH -> ER, abstract)] || || [BrainAreaLMC LMC] || [BrainRegionLMC_MM_VTA LMC.MM.VTA] || Ventral Tegmental Area || modulatory-da || uncertain ||[http://www.impulsecontroldisorders.org/html/cravings.html Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)] || || [BrainAreaNDM NDM] || [BrainRegionNDM_FD_TH_PV NDM.FD.TH.PV] || Paraventricular Nucleus of Thalamus || excitatory-glu || uncertain ||[http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)] || || [BrainAreaNSA NSA] || [BrainRegionNSA_NC_IT_TE NSA.NC.IT.TE] || Inferotemporal Cortex || feedforward-glu || uncertain ||[http://www.nature.com/nrn/journal/v3/n2/fig_tab/nrn726_F3.html McNaughton Spatial Processing Network (ITCortex -> EnthCortex, abstract)] || || || [BrainRegionNSA_NC_PH_PIR NSA.NC.PH.PIR] || Piriform Cortex || feedforward-glu || uncertain ||[http://www.sciencedirect.com/science/article/pii/S1571064507000243 KIV model of cortico-hippocampal formation with subcortical projections for motor actions (PC -> EC, abstract)] || || || [BrainRegionNSA_NC_STG_A3 NSA.NC.STG.A3] || Wernicke's area A3 || feedforward-glu || uncertain ||(unknown reference) || || || [BrainRegionNSA_NC_STG_A4 NSA.NC.STG.A4] || Wernicke's area A4 || feedforward-glu || uncertain ||(unknown reference) || *Outbound Region Connections:* || *Target Area* || *Target Region* || *Target Name* || *Type* || *Role* || *Reference* || || [BrainAreaFAM FAM] || [BrainRegionFAM_FT_AM_AB FAM.FT.AM.AB] || Accessory Basal Amygdaloid Nucleus || excitatory-glu || uncertain || [http://www.sciencedirect.com/science/article/pii/S030100820900183X Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)] || || || [BrainRegionFAM_FT_AM_LAVM FAM.FT.AM.LAVM] || Ventromedial Amygdaloid Nucleus || excitatory-glu || uncertain || [http://www.sciencedirect.com/science/article/pii/S030100820900183X Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)] || || [BrainAreaFEC FEC] || [BrainRegionFEC_FT_ACC_CORE FEC.FT.ACC.CORE] || Nucleus Accumbens Core || excitatory-glu || uncertain || [http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/biomodel/nucleus-accumbens.jpg Nucleus Accumbens (EC -> NACC, abstract)] || || [BrainAreaFMM FMM] || [BrainRegionFMM_FT_HC_CA1D FMM.FT.HC.CA1D] || Distal CA1 of Hippocampus || excitatory-glu || uncertain || [http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00061/full Neuronal projections in the hippocampus (ET -> CA1, abstract)] || || || [BrainRegionFMM_FT_HC_CA2 FMM.FT.HC.CA2] || Dorsolateral Cornu Ammonis of Hippocampus || excitatory-glu || uncertain || [http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin Amygdala and its network (EC -> HC, abstract)] || || || [BrainRegionFMM_FT_HC_CA3P FMM.FT.HC.CA3P] || Proximal CA3 of Hippocampus || excitatory-glu || uncertain || [http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00061/full Neuronal projections in the hippocampus (ET -> CA3, abstract)] || || || [BrainRegionFMM_FT_HC_DG FMM.FT.HC.DG] || Dentate Gyrus || excitatory-glu || uncertain || [http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00061/full Neuronal projections in the hippocampus (ET -> DG, abstract)] || || || [BrainRegionFMM_FT_HF_SUBP FMM.FT.HF.SUBP] || Proximal Subiculum || excitatory-glu || uncertain || [http://www.scholarpedia.org/article/Inferior_temporal_cortex Visual Path to Hippocampus (ER -> H, abstract)] || || [BrainAreaNDM NDM] || [BrainRegionNDM_FD_TH_MDM NDM.FD.TH.MDM] || Medial Mediodorsal Nucleus of Thalamus || excitatory-glu || uncertain || [http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html Contributions of Diencephalon to Recognition Memory (EC -> MDmc, abstract)] || = Thirdparty Circuits = (generated) * [http://learnmem.cshlp.org/content/18/6/384/F1.large.jpg Contributions of Diencephalon to Recognition Memory] - see [http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html Reference] (CT.RECOGNITION-MEMORY) AD=[BrainRegionFMM_FD_TH_AD Anterodorsal Nucleus,FMM.FD.TH.AD] AM=[BrainRegionNCP_FD_TH_AM Anteromedial Nucleus,NCP.FD.TH.AM] AN=Anterior Nucleus of Thalamus,FD.TH.AN (see [BrainCenterFD_TH_CR Cognitive Thalamus]) AV=[BrainRegionFMM_FD_TH_AV Anteroventral Nucleus,FMM.FD.TH.AV] CM=[BrainRegionFEC_FD_TH_CM Centromedian Nucleus of Thalamus,FEC.FD.TH.CM] DLPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see [BrainCenterNC_AL_LPFC Lateral Prefrontal Cortex]) EC=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex]) HC=Hippocampus,FMM.FT.HC (see [BrainCenterFMM_FT_HF Hippocampal Formation]) LD=[BrainRegionFMM_FD_TH_LD Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD] MB=[BrainRegionFMM_FD_MB_MMB Medial Mammillary Nucleus,FMM.FD.MB.MMB] MDmc=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see [BrainCenterFD_TH_CR Cognitive Thalamus]) MID=Midline Nuclear Group of Thalamus,FD.TH.MTH (see [BrainCenterFD_TH_CR Cognitive Thalamus]) MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex]) OFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex]) Parasub=[BrainRegionFMM_NC_PH_PAS Parasubiculum,FMM.NC.PH.PAS] Perirhinal=[BrainRegionFMM_NC_PH_PER Perirhinal Cortex,FMM.NC.PH.PER] PostCingulate=[BrainRegionNCP_NC_MPL_PSCG Posterior Cingulate Cortex,NCP.NC.MPL.PSCG] Presub=[BrainRegionFMM_NC_PH_PRS Presubiculum,FMM.NC.PH.PRS] Sub=Subiculum,FMM.FT.HF.SUB (see [BrainCenterFMM_FT_HF Hippocampal Formation]) SubPrePara=Subiculum,FMM.FT.HF.SUB (see [BrainCenterFMM_FT_HF Hippocampal Formation]) mPULV=[BrainRegionNPE_FD_TH_MPV Medial Pulvinar,NPE.FD.TH.MPV] unavailable * [http://ars.els-cdn.com/content/image/1-s2.0-S030100820900183X-gr4.jpg Simplified model of hippocampal formation anatomy] - see [http://www.sciencedirect.com/science/article/pii/S030100820900183X Reference] (CT.OPERATING-MODEL) Amyg=[BrainCenterFAM_FT_AM Amygdala,FAM.FT.AM] CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see [BrainCenterFMM_FT_HF Hippocampal Formation]) CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see [BrainCenterFMM_FT_HF Hippocampal Formation]) DG=[BrainRegionFMM_FT_HC_DG Dentate Gyrus,FMM.FT.HC.DG] EC=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex]) NACC=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia]) SUB=Subiculum,FMM.FT.HF.SUB (see [BrainCenterFMM_FT_HF Hippocampal Formation]) mPFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex]) unavailable * [http://www.scholarpedia.org/w/images/thumb/f/f2/ITCortex_pathway.jpg/400px-ITCortex_pathway.jpg Visual Path to Hippocampus] - see [http://www.scholarpedia.org/article/Inferior_temporal_cortex Reference] (CP.VISUAL-PATH-TO-HC) A=[BrainCenterFAM_FT_AM Amygdala,FAM.FT.AM] ER=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex]) H=[BrainCenterFMM_FT_HF Hippocampal Formation,FMM.FT.HF] IT=[BrainRegionNSA_NC_IT_TE Inferotemporal Cortex,NSA.NC.IT.TE] PRPH=[BrainRegionFMM_NC_PH_PER Perirhinal Cortex,FMM.NC.PH.PER] TEO=[BrainRegionNSA_NC_IT_TEO Preoccipital Inferotemporal Area,NSA.NC.IT.TEO] V1=[BrainRegionNSA_NC_OCC_V1 Primary Visual Cortex,NSA.NC.OCC.V1] V2=Secondary Visual Cortex,NSA.NC.OCC.V2 (see [BrainCenterNC_LOBE_OCC Occipital Lobe]) V4=Fusiform Gyrus,NSA.NC.OCC.V4 (see [BrainCenterNC_LOBE_OCC Occipital Lobe]) unavailable * [http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/biomodel/nucleus-accumbens.jpg Nucleus Accumbens] (unknown reference) (CF.NUCLEUUS-ACCUMBENS) CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see [BrainCenterFMM_FT_HF Hippocampal Formation]) CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see [BrainCenterFMM_FT_HF Hippocampal Formation]) EC=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex]) NACC=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia]) PAS=[BrainRegionFMM_NC_PH_PAS Parasubiculum,FMM.NC.PH.PAS] PRR=[BrainRegionFMM_NC_PH_PER Perirhinal Cortex,FMM.NC.PH.PER] SUB=Subiculum,FMM.FT.HF.SUB (see [BrainCenterFMM_FT_HF Hippocampal Formation]) unavailable * [http://sni.wpengine.com/wp-content/uploads/2015/05/3520/SNI-3-40-g001.png Amygdala and its network] - see [http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin Reference] (CF.AM-NET) BLN=[BrainRegionFAM_FT_AM_BP Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP] CEA=Central Amygdala,FAM.FT.AM.CEA (see [BrainCenterFAM_FT_AM Amygdala]) EC=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex]) HC=Hippocampus,FMM.FT.HC (see [BrainCenterFMM_FT_HF Hippocampal Formation]) HTS=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN] ITC=[BrainRegionNSA_NC_IT_TE Inferotemporal Cortex,NSA.NC.IT.TE] LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see [BrainCenterFAM_FT_AM Amygdala]) LHB=Lateral Habenula,FAM.FD.LHB (see [BrainCenterFAM_FD_HB Habenula]) MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see [BrainCenterFD_TH_CR Cognitive Thalamus]) MPFC=[BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex,NC.AL.OMPFC] NACC=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia]) PAG=[BrainRegionLMC_MM_PAG Periaqueductal Gray Matter,LMC.MM.PAG] RMTG=[BrainRegionFEC_HT_TG_RMTG Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG] STC=[BrainRegionNSA_NC_STG_A3 Wernicke's area A3,NSA.NC.STG.A3] VGDM=[BrainRegionLAC_HL_VGN Vagus Nucleus,LAC.HL.VGN] VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] unavailable * [http://www.frontiersin.org/files/Articles/46459/fpsyt-04-00061-HTML/image_m/fpsyt-04-00061-g002.jpg Neuronal projections in the hippocampus] - see [http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00061/full Reference] (CF.AM-HC) BLA=Basolateral Nuclear Complex,FAM.FT.AM.BL (see [BrainCenterFAM_FT_AM Amygdala]) CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see [BrainCenterFMM_FT_HF Hippocampal Formation]) CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see [BrainCenterFMM_FT_HF Hippocampal Formation]) DG=[BrainRegionFMM_FT_HC_DG Dentate Gyrus,FMM.FT.HC.DG] ET=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex]) unavailable = References = (generated) * http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html * http://www.sciencedirect.com/science/article/pii/S030100820900183X * http://www.scholarpedia.org/article/Inferior_temporal_cortex * http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin * http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00061/full