#summary Nucleus Accumbens Core
@@[Home] -> [BiologicalLifeResearch] -> [BrainAreaFEC] -> [BrainRegionFEC_FT_ACC_CORE]
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This page covers biological details of component Nucleus Accumbens Core.
Region is part of aHuman target integrated biological model.
* *Top-down path to region*: Forebrain Telencephalon -> [BrainCenterFEC_FT_BG Basal Ganglia] (FEC.FT.BG) -> Striatum (FEC.FT.ST) -> Ventral Striatum (FEC.FT.VST) -> Accumbens Nucleus (FEC.FT.ACC) -> [BrainRegionFEC_FT_ACC_CORE Nucleus Accumbens Core] (FEC.FT.ACC.CORE) (see [OverallMindMaps Mind Maps])
* *Type*: nucleus
* *Quality*: L0
* *Brain area*: [BrainAreaFEC Forebrain - Execution Control Area] (FEC)
* *Area circuit*: Motor Motivational Salience (FECLM)
* *Role*: basal.ganglia.striatum
* *Function*: cognitive processing of motor function related to reward and reinforcement; encodes new motor programs which facilitate acquisition of given reward in future
(generated)
= Components =
(generated)
* no child items defined
= Connectivity =
(generated)
http://ahuman.org/svn/ahwiki/images/dot/FEC.FT.ACC.CORE.dot.png
*Inbound Region Connections:*
|| *Source Area* || *Source Region* || *Source Name* || *Type* || *Role* || *Reference* ||
|| [BrainAreaFAM FAM] || [BrainRegionFAM_FD_TH_PT FAM.FD.TH.PT] || Paratenial Nucleus of Thalamus || excitatory-glu || uncertain ||(unknown reference) ||
|| || [BrainRegionFAM_FT_AM_BP FAM.FT.AM.BP] || Parvicellular Basal Amygdaloid Nucleus || excitatory-glu || uncertain ||[http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin Amygdala and its network (BLN -> NACC, abstract)] ||
|| [BrainAreaFMM FMM] || [BrainRegionFMM_FD_TH_RH FMM.FD.TH.RH] || Rhomboidal Nucleus of Thalamus || excitatory-glu || uncertain ||(unknown reference) ||
|| || [BrainRegionFMM_FT_HC_CA1D FMM.FT.HC.CA1D] || Distal CA1 of Hippocampus || excitatory-glu || uncertain ||[http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/biomodel/nucleus-accumbens.jpg Nucleus Accumbens (CA1 -> NACC, abstract)] ||
|| || [BrainRegionFMM_FT_HF_SUBD FMM.FT.HF.SUBD] || Distal Subiculum || excitatory-glu || uncertain ||[http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/biomodel/nucleus-accumbens.jpg Nucleus Accumbens (SUB -> NACC, abstract)] ||
|| || [BrainRegionFMM_FT_HF_SUBP FMM.FT.HF.SUBP] || Proximal Subiculum || excitatory-glu || uncertain ||[http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/biomodel/nucleus-accumbens.jpg Nucleus Accumbens (SUB -> NACC, abstract)] ||
|| || [BrainRegionFMM_NC_PH_LEC FMM.NC.PH.LEC] || Lateral Entorhinal Cortex || excitatory-glu || uncertain ||[http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/biomodel/nucleus-accumbens.jpg Nucleus Accumbens (EC -> NACC, abstract)] ||
|| || [BrainRegionFMM_NC_PH_PAS FMM.NC.PH.PAS] || Parasubiculum || excitatory-glu || uncertain ||[http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/biomodel/nucleus-accumbens.jpg Nucleus Accumbens (PAS -> NACC, abstract)] ||
|| || [BrainRegionFMM_NC_PH_PER FMM.NC.PH.PER] || Perirhinal Cortex || excitatory-glu || uncertain ||[http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/biomodel/nucleus-accumbens.jpg Nucleus Accumbens (PRR -> NACC, abstract)] ||
|| [BrainAreaNDM NDM] || [BrainRegionNDM_FD_TH_PV NDM.FD.TH.PV] || Paraventricular Nucleus of Thalamus || excitatory-glu || uncertain ||(unknown reference) ||
|| || [BrainRegionNDM_NC_AL_FPC NDM.NC.AL.FPC] || Lateral Frontopolar Cortex || excitatory-glu || uncertain ||[http://www.expertsmind.com/topic/emotion/affective-basal-ganglia-circuit-93570.aspx Affective basal ganglia circuit (OMPFC -> NACC, abstract)] ||
*Outbound Region Connections:*
|| *Target Area* || *Target Region* || *Target Name* || *Type* || *Role* || *Reference* ||
|| [BrainAreaFAM FAM] || [BrainRegionFAM_FD_LHB_LT FAM.FD.LHB.LT] || Lateral Habenula Lateral Part || inhibitory-gaba || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (NAc -> L, abstract)] ||
|| [BrainAreaFEC FEC] || [BrainRegionFEC_FT_SNC_MED FEC.FT.SNC.MED] || Substantia Nigra Pars Compacta Medial || inhibitory-gaba || uncertain || (unknown reference) ||
|| || [BrainRegionFEC_FT_SNR_MED FEC.FT.SNR.MED] || Substantia Nigra Pars Reticulata Medial || inhibitory-gaba || uncertain || [http://www.impulsecontroldisorders.org/html/cravings.html Craving (NACC -> SNr, abstract)] ||
|| || [BrainRegionFEC_FT_VP_DL FEC.FT.VP.DL] || Ventral Pallidum Dorsolateral || inhibitory-gaba || uncertain || [http://www.impulsecontroldisorders.org/html/cravings.html Craving (NACC -> VPAL, abstract)] ||
|| [BrainAreaLMC LMC] || [BrainRegionLMC_MM_VTA LMC.MM.VTA] || Ventral Tegmental Area || inhibitory-gaba || uncertain || [http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity Reward circuit of human brain (NACC -> VTA, abstract)] ||
= Thirdparty Circuits =
(generated)
* [http://www.nature.com/nrn/journal/v5/n3/images/nrn1345-i1.jpg Saccadic Vision] - see [http://www.nature.com/nrn/journal/v5/n3/box/nrn1345_BX1.html Reference] (CP.SACCADIC-VISION)
BG=[BrainCenterFEC_FT_BG Basal Ganglia,FEC.FT.BG]
CN=Caudate Nucleus,FEC.FT.CN (see [BrainCenterFEC_FT_BG Basal Ganglia])
CR=Cerebellum,LLC.HT.CR (see [BrainCenterLLC_HT_CRC Cerebellar Complex])
FrontalCortex=Anterior Lobe,NC.LOBE.ANT
GPe=Globus Pallidus External,FEC.FT.GPE (see [BrainCenterFEC_FT_BG Basal Ganglia])
LGN=[BrainRegionNSA_FD_LGN Lateral Geniculate Nucleus,NSA.FD.LGN]
LIP=[BrainRegionNPE_NC_IPS_LIP Lateral Intraparietal Sulcus,NPE.NC.IPS.LIP]
RF=[BrainCenterHT_RF Pontine Reticular Formation,HT.RF]
Retina=[BrainRegionLPC_FD_RT Retinal Nucleus,LPC.FD.RT]
SCi=Superior Colliculus,MM.SC (see [BrainCenterMM_REF Reflexes Nuclei of Midbrain Mesencephalon])
SCs=Superior Colliculus,MM.SC (see [BrainCenterMM_REF Reflexes Nuclei of Midbrain Mesencephalon])
SNpr=[BrainRegionFEC_FT_SNR_DL Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL]
STN=Subthalamic Nucleus,FEC.FD.STN (see [BrainCenterFEC_FD_STA Subthalamus Area])
Thalamus=Thalamus,FD.TH
VisualCortex=[BrainCenterNC_LOBE_OCC Occipital Lobe,NC.LOBE.OCC]
* [http://www.nature.com/nrendo/journal/v6/n8/images/nrendo.2010.93-f1.jpg Bowels control brain: gut hormones and obesity] - see [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Reference] (CP.BOWELS)
AMY=[BrainCenterFAM_FT_AM Amygdala,FAM.FT.AM]
ARC=[BrainRegionLAC_FD_HT_AR Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR]
DS=Dorsal Striatum,FEC.FT.DST (see [BrainCenterFEC_FT_BG Basal Ganglia])
LHA=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN]
ME=[BrainRegionTARGET_TEA_ENDOCRINE Endocrine Glands,TARGET.TEA.ENDOCRINE]
NAc=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia])
NTS=[BrainRegionLPC_HL_SOL Solitary Nucleus,LPC.HL.SOL]
OFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex])
PBN=[BrainRegionLPC_HT_PRF_PB Parabrachial Nucleus,LPC.HT.PRF.PB]
PVN=[BrainRegionLAC_FD_HT_PV Paraventricular Nucleus,LAC.FD.HT.PV]
VMN=[BrainRegionLAC_FD_HT_VM Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM]
VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA]
* [http://neurowiki2012.wikispaces.com/file/view/Reward_circuit.jpg/315908202/Reward_circuit.jpg Reward circuit of human brain] - see [http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity Reference] (CF.REWARD-CIRCUIT)
AM=[BrainCenterFAM_FT_AM Amygdala,FAM.FT.AM]
HC=Hippocampus,FMM.FT.HC (see [BrainCenterFMM_FT_HF Hippocampal Formation])
NACC=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia])
PFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex])
VPAL=Ventral Pallidum,FEC.FT.VP (see [BrainCenterFEC_FT_BG Basal Ganglia])
VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA]
* [http://d2avczb82rh8fa.cloudfront.net/content/jn/107/10/2633/F1.large.jpg Connectivity map of the habenula] - see [http://jn.physiology.org/content/107/10/2633 Reference] (CF.HB-CONN)
CPu=Striatum,FEC.FT.ST (see [BrainCenterFEC_FT_BG Basal Ganglia])
EP=[BrainRegionFAM_FT_EPF Endopiriform Nucleus,FAM.FT.EPF]
Hippo=Hippocampus,FMM.FT.HC (see [BrainCenterFMM_FT_HF Hippocampal Formation])
IPN=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD]
L=Lateral Habenula,FAM.FD.LHB (see [BrainCenterFAM_FD_HB Habenula])
LH=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN]
M=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB]
NAc=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia])
PAG=[BrainRegionLMC_MM_PAG Periaqueductal Gray Matter,LMC.MM.PAG]
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see [BrainCenterHL_RF Medullary Reticular Formation])
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see [BrainCenterFEC_FT_BG Basal Ganglia])
Septum=[BrainCenterFAM_FT_SEP Septal Nuclei,FAM.FT.SEP]
VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA]
* [http://www.impulsecontroldisorders.org/images/8-Urges9proof.jpg Craving] - see [http://www.impulsecontroldisorders.org/html/cravings.html Reference] (CF.CRAVING)
NACC=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia])
OMPFC=Orbitofrontal Cortex,NC.AL.OPFC (see [BrainCenterNC_AL_OMPFC Orbitomedial Prefrontal Cortex])
SNr=[BrainRegionFEC_FT_SNR_MED Substantia Nigra Pars Reticulata Medial,FEC.FT.SNR.MED]
VPAL=Ventral Pallidum,FEC.FT.VP (see [BrainCenterFEC_FT_BG Basal Ganglia])
VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA]
= References =
(generated)
* http://www.nature.com/nrn/journal/v5/n3/box/nrn1345_BX1.html
* http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html
* http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity
* http://jn.physiology.org/content/107/10/2633
* http://www.impulsecontroldisorders.org/html/cravings.html