#summary Medial Septal Nucleus
@@[Home] -> [BiologicalLifeResearch] -> [BrainAreaFAM] -> [BrainRegionFAM_FT_SEP_MED]
----
This page covers biological details of component Medial Septal Nucleus.
Region is part of aHuman target integrated biological model.
* *Top-down path to region*: Forebrain Telencephalon -> Extended Amygdala (FAM.FT.EXTAM) -> [BrainCenterFAM_FT_SEP Septal Nuclei] (FAM.FT.SEP) -> Dorsal Septal Nucleus (FAM.FT.SEP.DS) -> Medial Septal Group (FAM.FT.SEP.MG) -> [BrainRegionFAM_FT_SEP_MED Medial Septal Nucleus] (FAM.FT.SEP.MED) (see [OverallMindMaps Mind Maps])
* *Type*: nucleus
* *Quality*: L0
* *Brain area*: [BrainAreaFAM Forebrain - Affective Motivations Area] (FAM)
* *Area circuit*: Memory Formation Affective Focus (FAMXMF)
* *Role*: processor.affective.memory
* *Function*: affect HC for spatial learning, generation of theta waves
* *Notes to function*:
* output nucleus
* projections from AM and HC overlap
* control theta rythm and exprolatory behavior
* from/to MFB to fornix fimbria
(generated)
= Components =
(generated)
* no child items defined
= Connectivity =
(generated)
http://ahuman.org/svn/ahwiki/images/dot/FAM.FT.SEP.MED.dot.png
*Inbound Region Connections:*
|| *Source Area* || *Source Region* || *Source Name* || *Type* || *Role* || *Reference* ||
|| [BrainAreaLAC LAC] || [BrainRegionLAC_FD_HT_SUM LAC.FD.HT.SUM] || Supramammillary Nucleus || excitatory-glu || uncertain ||[http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F4.html Medial mammillary nucleus and theta rhythm (SupraMM -> SEP, abstract)] ||
*Outbound Region Connections:*
|| *Target Area* || *Target Region* || *Target Name* || *Type* || *Role* || *Reference* ||
|| [BrainAreaFAM FAM] || [BrainRegionFAM_FD_MHB FAM.FD.MHB] || Medial Habenula || modulatory-ach || uncertain || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (MS -> MHb)] ||
|| [BrainAreaFEC FEC] || [BrainRegionFEC_FD_TH_PF FEC.FD.TH.PF] || Parafascicular Nucleus of Thalamus || modulatory-ach || uncertain || (unknown reference) ||
|| [BrainAreaFMM FMM] || [BrainRegionFMM_FD_MB_LMB FMM.FD.MB.LMB] || Lateral Mammillary Nucleus || modulatory-ach || uncertain || [http://www.thebrainlabs.com Cingulate Gyrus (SEP -> HT, abstract)] ||
|| || [BrainRegionFMM_FD_MB_MMB FMM.FD.MB.MMB] || Medial Mammillary Nucleus || inhibitory-gaba || uncertain || [http://www.thebrainlabs.com Cingulate Gyrus (SEP -> HT, abstract)] ||
|| [BrainAreaNCP NCP] || [BrainRegionNCP_NC_MPL_RSC NCP.NC.MPL.RSC] || Retrosplenial Cortex || modulatory-ach || uncertain || [http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F4.html Medial mammillary nucleus and theta rhythm (SEP -> RSP, abstract)] ||
|| [BrainAreaNDM NDM] || [BrainRegionNDM_FD_TH_MDM NDM.FD.TH.MDM] || Medial Mediodorsal Nucleus of Thalamus || modulatory-ach || uncertain || [http://what-when-how.com/neuroscience/the-thalamus-and-cerebral-cortex-integrative-systems-part-2/ Thalamocortical relationships (s1MD -> MD, abstract)] ||
= Thirdparty Circuits =
(generated)
* [http://www.nature.com/nrn/journal/v5/n1/images/nrn1299-f4.jpg Medial mammillary nucleus and theta rhythm] - see [http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F4.html Reference] (CT.MMB-THETA)
AVTH=[BrainRegionFMM_FD_TH_AV Anteroventral Nucleus,FMM.FD.TH.AV]
HF=[BrainCenterFMM_FT_HF Hippocampal Formation,FMM.FT.HF]
MMB=[BrainRegionFMM_FD_MB_MMB Medial Mammillary Nucleus,FMM.FD.MB.MMB]
RSP=[BrainRegionNCP_NC_MPL_RSC Retrosplenial Cortex,NCP.NC.MPL.RSC]
SEP=[BrainCenterFAM_FT_SEP Septal Nuclei,FAM.FT.SEP]
SupraMM=[BrainRegionLAC_FD_HT_SUM Supramammillary Nucleus,LAC.FD.HT.SUM]
VTN=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA]
* [http://www.thebrainlabs.com/Images/cingulate_gyrus.gif Cingulate Gyrus] - see [http://www.thebrainlabs.com Reference] (CT.CINGULATE-CORTEX)
CG=[BrainRegionNCP_NC_MPL_PSCG Posterior Cingulate Cortex,NCP.NC.MPL.PSCG]
ET=Entorhinal Cortex,FMM.NC.PH.ET (see [BrainCenterNC_PHA_RH Rhinal Cortex])
HC=Hippocampus,FMM.FT.HC (see [BrainCenterFMM_FT_HF Hippocampal Formation])
HT=[BrainCenterFD_HT Hypothalamus,FD.HT]
MB=Mammillary Body,FD.MB (see [BrainCenterFD_HT Hypothalamus])
SEP=[BrainCenterFAM_FT_SEP Septal Nuclei,FAM.FT.SEP]
TH=Anterior Nucleus of Thalamus,FD.TH.AN (see [BrainCenterFD_TH_CR Cognitive Thalamus])
* [http://what-when-how.com/wp-content/uploads/2012/04/tmp3649_thumb1_thumb.jpg Thalamocortical relationships] - see [http://what-when-how.com/neuroscience/the-thalamus-and-cerebral-cortex-integrative-systems-part-2/ Reference] (CL.THALAMUS-PROJECTIONS)
A=Anterior Nucleus of Thalamus,FD.TH.AN (see [BrainCenterFD_TH_CR Cognitive Thalamus])
CM=[BrainRegionFEC_FD_TH_CM Centromedian Nucleus of Thalamus,FEC.FD.TH.CM]
LD=[BrainRegionFMM_FD_TH_LD Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD]
LGN=[BrainRegionNSA_FD_LGN Lateral Geniculate Nucleus,NSA.FD.LGN]
LP=[BrainRegionNPE_FD_TH_LP Lateral Posterior Nucleus of Thalamus,NPE.FD.TH.LP]
MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see [BrainCenterFD_TH_CR Cognitive Thalamus])
MGN=[BrainRegionNSA_FD_TH_MGB Medial Geniculate Body,NSA.FD.TH.MGB]
P=Ventral Posterior Nuclei,NSA.FD.TH.VP (see [BrainCenterFD_TH_SR Sensory Thalamus])
VA=[BrainRegionNMA_FD_TH_VA Ventral Anterior Nucleus,NMA.FD.TH.VA]
VL=[BrainRegionNMA_FD_TH_VL Ventral Lateral Nucleus,NMA.FD.TH.VL]
VPL=[BrainRegionNCP_FD_TH_VPL Ventral Posterolateral Nucleus,NCP.FD.TH.VPL]
VPM=[BrainRegionNCP_FD_TH_VPM Ventral Posteromedial Nucleus,NCP.FD.TH.VPM]
pA=[BrainRegionNCP_NC_MPL_PSCG Posterior Cingulate Cortex,NCP.NC.MPL.PSCG]
pCM=Dorsal Putamen,FEC.FT.DPU (see [BrainCenterFEC_FT_BG Basal Ganglia])
pLD=Anterior Cingulate Cortex,NC.AL.ACG (see [BrainCenterNC_ACG Anterior Cingulate Area])
pLGN=[BrainRegionNSA_NC_OCC_V1 Primary Visual Cortex,NSA.NC.OCC.V1]
pLP=[BrainCenterNC_SPL Superior Parietal Lobule,NC.SPL]
pMD=Prefrontal Cortex,NC.AL.PFC
pMGN=[BrainRegionNSA_NC_TTG_A1 Primary Auditory Cortex,NSA.NC.TTG.A1]
pP=[BrainCenterNC_INS Insular Cortex,NC.INS]
pVA=[BrainCenterNMA_NC_SMC Supplementary Motor Cortex,NMA.NC.SMC]
pVL=[BrainRegionNMA_NC_MC Motor Cortex,NMA.NC.MC]
pVPL=[BrainRegionNCP_NC_PG_S1 Primary Somatosensory Cortex,NCP.NC.PG.S1]
pVPM=[BrainRegionNCP_NC_PO_PCC Precentral Cortex,NCP.NC.PO.PCC]
s1A=Subiculum,FMM.FT.HF.SUB (see [BrainCenterFMM_FT_HF Hippocampal Formation])
s1MD=[BrainCenterFAM_FT_SEP Septal Nuclei,FAM.FT.SEP]
s1P=[BrainRegionLPC_SC_IZ_CCV Central Cervical Nucleus,LPC.SC.IZ.CCV]
s1VL=[BrainRegionLLC_HT_CR_DN Dentate Nucleus,LLC.HT.CR.DN]
s2A=Mammillary Body,FD.MB (see [BrainCenterFD_HT Hypothalamus])
s2MD=[BrainRegionNSA_NC_PH_PIR Piriform Cortex,NSA.NC.PH.PIR]
s2P=[BrainRegionLPC_HT_PN_PTR Principal Trigeminal Nucleus,LPC.HT.PN.PTR]
s2VL=[BrainCenterFEC_FT_BG Basal Ganglia,FEC.FT.BG]
s3MD=Prefrontal Cortex,NC.AL.PFC
sCM=Globus Pallidus Internal,FEC.FT.GPI (see [BrainCenterFEC_FT_BG Basal Ganglia])
sLD=[BrainCenterNC_SPL Superior Parietal Lobule,NC.SPL]
sLP=Superior Colliculus,MM.SC (see [BrainCenterMM_REF Reflexes Nuclei of Midbrain Mesencephalon])
sVA=[BrainCenterFEC_FT_BG Basal Ganglia,FEC.FT.BG]
sVPL=Marginal Nucleus,LPC.SC.PH.MG (see [BrainCenterBMA_SC_PH Posterior/Dorsal Horn])
sVPM=[BrainRegionLPC_HL_SOL Solitary Nucleus,LPC.HL.SOL]
* [http://www.nature.com/neuro/journal/v17/n9/images/nn.3779-F2.jpg Both LHb and MHb control the dopaminergic and serotonergic systems] - see [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Reference] (CF.HB-DA5HT)
DBB=[BrainRegionFAM_FT_SEP_DBB Diagonal Band of Broca,FAM.FT.SEP.DBB]
DRN=[BrainRegionLMC_MM_RP_DRN Dorsal Raphe Nucleus,LMC.MM.RP.DRN]
GPb=Dorsal Pallidum,FEC.FT.DP (see [BrainCenterFEC_FT_BG Basal Ganglia])
IPN=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD]
LHA=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN]
LHbL=[BrainRegionFAM_FD_LHB_LT Lateral Habenula Lateral Part,FAM.FD.LHB.LT]
LHbM=[BrainRegionFAM_FD_LHB_MED Lateral Habenula Medial Part,FAM.FD.LHB.MED]
LPO=[BrainRegionLAC_FD_HT_VLPO Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO]
LS=[BrainRegionFAM_FT_SEP_LT Lateral Septal Nucleus,FAM.FT.SEP.LT]
MHb=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB]
MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see [BrainCenterHL_RF Medullary Reticular Formation])
MS=[BrainRegionFAM_FT_SEP_MED Medial Septal Nucleus,FAM.FT.SEP.MED]
PS=Posterior Septal Group,FAM.FT.SEP.PG (see [BrainCenterFAM_FT_SEP Septal Nuclei])
RMTg=[BrainRegionFEC_HT_TG_RMTG Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG]
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see [BrainCenterFEC_FT_BG Basal Ganglia])
VP=Ventral Pallidum,FEC.FT.VP (see [BrainCenterFEC_FT_BG Basal Ganglia])
VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA]
= References =
(generated)
* http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F4.html
* http://www.thebrainlabs.com
* http://what-when-how.com/neuroscience/the-thalamus-and-cerebral-cortex-integrative-systems-part-2/
* http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html