#summary Medial Habenula
@@[Home] -> [BiologicalLifeResearch] -> [BrainAreaFAM] -> [BrainRegionFAM_FD_MHB]
----
This page covers biological details of component Medial Habenula.
Region is part of aHuman target integrated biological model.
* *Top-down path to region*: Forebrain Diencephalon -> [BrainCenterFAM_FD_HB Habenula] (FAM.FD.HB) -> [BrainRegionFAM_FD_MHB Medial Habenula] (FAM.FD.MHB) (see [OverallMindMaps Mind Maps])
* *Type*: nucleus
* *Quality*: L0
* *Brain area*: [BrainAreaFAM Forebrain - Affective Motivations Area] (FAM)
* *Area circuit*: Reward Emotions Control (FAMXREC)
* *Role*: processor.affective
* *Function*: Encoding negative feedback, indirect
* *Notes to function*:
* affects VTA, dorsal raphe but via interpeduncular nucleus
(generated)
= Components =
(generated)
* no child items defined
= Connectivity =
(generated)
http://ahuman.org/svn/ahwiki/images/dot/FAM.FD.MHB.dot.png
*Inbound Region Connections:*
|| *Source Area* || *Source Region* || *Source Name* || *Type* || *Role* || *Reference* ||
|| [BrainAreaFAM FAM] || [BrainRegionFAM_FT_SEP_BAC FAM.FT.SEP.BAC] || Bed Nucleus of Anterior Commissure || excitatory-glu || uncertain ||[http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (Septum -> M, abstract)] ||
|| || [BrainRegionFAM_FT_SEP_DBB FAM.FT.SEP.DBB] || Diagonal Band of Broca || inhibitory-gaba || uncertain ||[http://www.scholarpedia.org/article/Habenula Habenula Connections (DBB -> MHb)] ||
|| || [BrainRegionFAM_FT_SEP_MED FAM.FT.SEP.MED] || Medial Septal Nucleus || modulatory-ach || uncertain ||[http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (MS -> MHb)] ||
|| || [BrainRegionFAM_FT_SEP_SF FAM.FT.SEP.SF] || Septofimbrial Nucleus || inhibitory-gaba || uncertain ||[http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (Septum -> M, abstract)] ||
|| || [BrainRegionFAM_FT_SEP_TR FAM.FT.SEP.TR] || Triangular Septal Nucleus || inhibitory-gaba || uncertain ||[http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (Septum -> M, abstract)] ||
|| [BrainAreaFEC FEC] || [BrainRegionFEC_FT_ACC_SH FEC.FT.ACC.SH] || Nucleus Accumbens Shell || inhibitory-gaba || uncertain ||[http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (NAc -> M, abstract)] ||
|| [BrainAreaLMC LMC] || [BrainRegionLMC_HT_LC LMC.HT.LC] || Locus Coeruleus || modulatory-ne || uncertain ||[http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> MHB)] ||
*Outbound Region Connections:*
|| *Target Area* || *Target Region* || *Target Name* || *Type* || *Role* || *Reference* ||
|| [BrainAreaFAM FAM] || [BrainRegionFAM_FD_LHB_MED FAM.FD.LHB.MED] || Lateral Habenula Medial Part || excitatory-glu || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (M -> L, abstract)] ||
|| [BrainAreaFEC FEC] || [BrainRegionFEC_HT_TG_IPD FEC.HT.TG.IPD] || Interpeduncular Nucleus || excitatory-glu || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (M -> IPN)] ||
|| [BrainAreaTEA TEA] || [BrainRegionTARGET_TEA_ENDOCRINE TARGET.TEA.ENDOCRINE] || Endocrine Glands || endocrine-pineal-gland || (none) || [http://www.scholarpedia.org/article/Habenula Habenula Connections (MHb -> PB)] ||
= Thirdparty Circuits =
(generated)
* [http://www.scholarpedia.org/w/images/thumb/2/2d/Hb-connections-small.jpg/800px-Hb-connections-small.jpg Habenula Connections] - see [http://www.scholarpedia.org/article/Habenula Reference] (CF.HB-CONNECTIONS)
CPu=Striatum,FEC.FT.ST (see [BrainCenterFEC_FT_BG Basal Ganglia])
DBB=[BrainRegionFAM_FT_SEP_DBB Diagonal Band of Broca,FAM.FT.SEP.DBB]
DR=[BrainRegionLMC_MM_RP_DRN Dorsal Raphe Nucleus,LMC.MM.RP.DRN]
GPi=Globus Pallidus Internal,FEC.FT.GPI (see [BrainCenterFEC_FT_BG Basal Ganglia])
IP=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD]
LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (see [BrainCenterFD_HT Hypothalamus])
LHb=Lateral Habenula,FAM.FD.LHB (see [BrainCenterFAM_FD_HB Habenula])
LPO=[BrainRegionLAC_FD_HT_VLPO Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO]
MHb=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB]
MR=[BrainRegionLMC_MM_RP_SUC Superior Central Raphe Nucleus,LMC.MM.RP.SUC]
PB=[BrainRegionTARGET_TEA_ENDOCRINE Endocrine Glands,TARGET.TEA.ENDOCRINE]
S=[BrainCenterFAM_FT_SEP Septal Nuclei,FAM.FT.SEP]
SNc=[BrainRegionFEC_FT_SNC_LT Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT]
VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA]
* [http://d2avczb82rh8fa.cloudfront.net/content/jn/107/10/2633/F1.large.jpg Connectivity map of the habenula] - see [http://jn.physiology.org/content/107/10/2633 Reference] (CF.HB-CONN)
CPu=Striatum,FEC.FT.ST (see [BrainCenterFEC_FT_BG Basal Ganglia])
EP=[BrainRegionFAM_FT_EPF Endopiriform Nucleus,FAM.FT.EPF]
Hippo=Hippocampus,FMM.FT.HC (see [BrainCenterFMM_FT_HF Hippocampal Formation])
IPN=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD]
L=Lateral Habenula,FAM.FD.LHB (see [BrainCenterFAM_FD_HB Habenula])
LH=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN]
M=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB]
NAc=Accumbens Nucleus,FEC.FT.ACC (see [BrainCenterFEC_FT_BG Basal Ganglia])
PAG=[BrainRegionLMC_MM_PAG Periaqueductal Gray Matter,LMC.MM.PAG]
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see [BrainCenterHL_RF Medullary Reticular Formation])
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see [BrainCenterFEC_FT_BG Basal Ganglia])
Septum=[BrainCenterFAM_FT_SEP Septal Nuclei,FAM.FT.SEP]
VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA]
* [http://dgr.brain.riken.jp/files/Connectivity_hab_eng.jpg Exploring role of habenula in emotional behaviors] - see [http://dgr.brain.riken.jp/AsymmetryE.html Reference] (CF.ZEBRAFISH)
LHb=Lateral Habenula,FAM.FD.LHB (see [BrainCenterFAM_FD_HB Habenula])
MHb=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB]
* [http://www.nature.com/nrn/journal/v11/n6/images/nrn2849-f7.jpg Contribution of nAChR subunits to nicotine withdrawal symptoms] - see [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Reference] (CF.HB-NICOTINE)
IPN=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD]
LC=[BrainRegionLMC_HT_LC Locus Coeruleus,LMC.HT.LC]
LHB=Lateral Habenula,FAM.FD.LHB (see [BrainCenterFAM_FD_HB Habenula])
MHB=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB]
* [http://www.nature.com/neuro/journal/v17/n9/images/nn.3779-F2.jpg Both LHb and MHb control the dopaminergic and serotonergic systems] - see [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Reference] (CF.HB-DA5HT)
DBB=[BrainRegionFAM_FT_SEP_DBB Diagonal Band of Broca,FAM.FT.SEP.DBB]
DRN=[BrainRegionLMC_MM_RP_DRN Dorsal Raphe Nucleus,LMC.MM.RP.DRN]
GPb=Dorsal Pallidum,FEC.FT.DP (see [BrainCenterFEC_FT_BG Basal Ganglia])
IPN=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD]
LHA=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN]
LHbL=[BrainRegionFAM_FD_LHB_LT Lateral Habenula Lateral Part,FAM.FD.LHB.LT]
LHbM=[BrainRegionFAM_FD_LHB_MED Lateral Habenula Medial Part,FAM.FD.LHB.MED]
LPO=[BrainRegionLAC_FD_HT_VLPO Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO]
LS=[BrainRegionFAM_FT_SEP_LT Lateral Septal Nucleus,FAM.FT.SEP.LT]
MHb=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB]
MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see [BrainCenterHL_RF Medullary Reticular Formation])
MS=[BrainRegionFAM_FT_SEP_MED Medial Septal Nucleus,FAM.FT.SEP.MED]
PS=Posterior Septal Group,FAM.FT.SEP.PG (see [BrainCenterFAM_FT_SEP Septal Nuclei])
RMTg=[BrainRegionFEC_HT_TG_RMTG Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG]
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see [BrainCenterFEC_FT_BG Basal Ganglia])
VP=Ventral Pallidum,FEC.FT.VP (see [BrainCenterFEC_FT_BG Basal Ganglia])
VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA]
* [http://rstb.royalsocietypublishing.org/content/royptb/364/1519/1005/F1.large.jpg Connectivity of dorsal diencephalic conduction system] - see [http://rstb.royalsocietypublishing.org/content/364/1519/1005 Reference] (CF.HB-ASYMM)
IPN=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD]
LHb=Lateral Habenula,FAM.FD.LHB (see [BrainCenterFAM_FD_HB Habenula])
MHb=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB]
= References =
(generated)
* http://www.scholarpedia.org/article/Habenula
* http://jn.physiology.org/content/107/10/2633
* http://dgr.brain.riken.jp/AsymmetryE.html
* http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html
* http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html
* http://rstb.royalsocietypublishing.org/content/364/1519/1005