#summary Lateral Habenula Medial Part @@[Home] -> [BiologicalLifeResearch] -> [BrainAreaFAM] -> [BrainRegionFAM_FD_LHB_MED] ---- This page covers biological details of component Lateral Habenula Medial Part. Region is part of aHuman target integrated biological model. * *Top-down path to region*: Forebrain Diencephalon -> [BrainCenterFAM_FD_HB Habenula] (FAM.FD.HB) -> Lateral Habenula (FAM.FD.LHB) -> [BrainRegionFAM_FD_LHB_MED Lateral Habenula Medial Part] (FAM.FD.LHB.MED) (see [OverallMindMaps Mind Maps]) * *Type*: nucleus * *Quality*: L0 * *Brain area*: [BrainAreaFAM Forebrain - Affective Motivations Area] (FAM) * *Area circuit*: Acquisition of Avoidance Responses (FAMXAA) * *Role*: processor.affective.avoidance * *Function*: Encoding negative feedback, direct, Septal (generated) = Components = (generated) * no child items defined = Connectivity = (generated) http://ahuman.org/svn/ahwiki/images/dot/FAM.FD.LHB.MED.dot.png *Inbound Region Connections:* || *Source Area* || *Source Region* || *Source Name* || *Type* || *Role* || *Reference* || || [BrainAreaFAM FAM] || [BrainRegionFAM_FD_MHB FAM.FD.MHB] || Medial Habenula || excitatory-glu || uncertain ||[http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (M -> L, abstract)] || || || [BrainRegionFAM_FT_SEP_DBB FAM.FT.SEP.DBB] || Diagonal Band of Broca || inhibitory-gaba || uncertain ||[http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (DBB -> LHbM)] || || || [BrainRegionFAM_FT_SEP_LT FAM.FT.SEP.LT] || Lateral Septal Nucleus || inhibitory-gaba || uncertain ||[http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LS -> LHbM)] || || [BrainAreaFEC FEC] || [BrainRegionFEC_FT_VP_VM FEC.FT.VP.VM] || Ventral Pallidum Ventromedial || inhibitory-gaba || uncertain ||[http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (VP -> LHbM, abstract)] || || [BrainAreaLAC LAC] || [BrainRegionLAC_FD_HT_LTN LAC.FD.HT.LTN] || Lateral Hypothalamic Nucleus || excitatory-glu || uncertain ||[http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHA -> LHbM)] || || || [BrainRegionLAC_FD_HT_VLPO LAC.FD.HT.VLPO] || Ventrolateral Preoptic Nucleus || excitatory-glu || uncertain ||[http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM)] || || [BrainAreaLMC LMC] || [BrainRegionLMC_HT_LC LMC.HT.LC] || Locus Coeruleus || modulatory-ne || uncertain ||[http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)] || *Outbound Region Connections:* || *Target Area* || *Target Region* || *Target Name* || *Type* || *Role* || *Reference* || || [BrainAreaFAM FAM] || [BrainRegionFAM_HT_TG_NI FAM.HT.TG.NI] || Incertus Nucleus || excitatory-glu || uncertain || [http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> NI)] || || [BrainAreaFEC FEC] || [BrainRegionFEC_FT_SNC_LT FEC.FT.SNC.LT] || Substantia Nigra Pars Compacta Lateral || excitatory-glu || uncertain || [http://www.scholarpedia.org/article/Habenula Habenula Connections (LHb -> SNc, abstract)] || || || [BrainRegionFEC_HT_TG_RMTG FEC.HT.TG.RMTG] || Rostromedial Tegmental Nucleus || excitatory-glu || uncertain || [http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> RMTg)] || || [BrainAreaLMC LMC] || [BrainRegionLMC_HL_RP_MG LMC.HL.RP.MG] || Raphe Magnus Nucleus || excitatory-glu || uncertain || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)] || || || [BrainRegionLMC_HT_TG_LDT LMC.HT.TG.LDT] || Laterodorsal Tegmental Nucleus || excitatory-glu || uncertain || [http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> DTG)] || || || [BrainRegionLMC_MM_RP_DRN LMC.MM.RP.DRN] || Dorsal Raphe Nucleus || excitatory-glu || uncertain || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)] || || || [BrainRegionLMC_MM_RP_SUC LMC.MM.RP.SUC] || Superior Central Raphe Nucleus || excitatory-glu || uncertain || [http://www.scholarpedia.org/article/Habenula Habenula Connections (LHb -> MR, abstract)] || || || [BrainRegionLMC_MM_VTA LMC.MM.VTA] || Ventral Tegmental Area || excitatory-glu || uncertain || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA)] || = Thirdparty Circuits = (generated) * [http://www.frontiersin.org/files/Articles/70852/fnhum-07-00826-HTML/image_m/fnhum-07-00826-g002.jpg Regulation of the rapid eye movement (REM) sleep by habenular projection] - see [http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full Reference] (CF.REM-HB) DBB=[BrainRegionFAM_FT_SEP_DBB Diagonal Band of Broca,FAM.FT.SEP.DBB] DTG=[BrainRegionLMC_HT_TG_LDT Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG] EPN=[BrainRegionFAM_FT_EPF Endopiriform Nucleus,FAM.FT.EPF] GPi=Globus Pallidus Internal,FEC.FT.GPI (see [BrainCenterFEC_FT_BG Basal Ganglia]) LHT=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN] LHbL=[BrainRegionFAM_FD_LHB_LT Lateral Habenula Lateral Part,FAM.FD.LHB.LT] LHbM=[BrainRegionFAM_FD_LHB_MED Lateral Habenula Medial Part,FAM.FD.LHB.MED] NI=[BrainRegionFAM_HT_TG_NI Incertus Nucleus,FAM.HT.TG.NI] RMTg=[BrainRegionFEC_HT_TG_RMTG Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG] Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see [BrainCenterHL_RF Medullary Reticular Formation]) SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see [BrainCenterFEC_FT_BG Basal Ganglia]) VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] VTG=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTG] unavailable * [http://www.nature.com/neuro/journal/v17/n9/images/nn.3779-F2.jpg Both LHb and MHb control the dopaminergic and serotonergic systems] - see [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Reference] (CF.HB-DA5HT) DBB=[BrainRegionFAM_FT_SEP_DBB Diagonal Band of Broca,FAM.FT.SEP.DBB] DRN=[BrainRegionLMC_MM_RP_DRN Dorsal Raphe Nucleus,LMC.MM.RP.DRN] GPb=Dorsal Pallidum,FEC.FT.DP (see [BrainCenterFEC_FT_BG Basal Ganglia]) IPN=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD] LHA=[BrainRegionLAC_FD_HT_LTN Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN] LHbL=[BrainRegionFAM_FD_LHB_LT Lateral Habenula Lateral Part,FAM.FD.LHB.LT] LHbM=[BrainRegionFAM_FD_LHB_MED Lateral Habenula Medial Part,FAM.FD.LHB.MED] LPO=[BrainRegionLAC_FD_HT_VLPO Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO] LS=[BrainRegionFAM_FT_SEP_LT Lateral Septal Nucleus,FAM.FT.SEP.LT] MHb=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB] MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see [BrainCenterHL_RF Medullary Reticular Formation]) MS=[BrainRegionFAM_FT_SEP_MED Medial Septal Nucleus,FAM.FT.SEP.MED] PS=Posterior Septal Group,FAM.FT.SEP.PG (see [BrainCenterFAM_FT_SEP Septal Nuclei]) RMTg=[BrainRegionFEC_HT_TG_RMTG Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG] SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see [BrainCenterFEC_FT_BG Basal Ganglia]) VP=Ventral Pallidum,FEC.FT.VP (see [BrainCenterFEC_FT_BG Basal Ganglia]) VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] unavailable * [http://www.scholarpedia.org/w/images/thumb/2/2d/Hb-connections-small.jpg/800px-Hb-connections-small.jpg Habenula Connections] - see [http://www.scholarpedia.org/article/Habenula Reference] (CF.HB-CONNECTIONS) CPu=Striatum,FEC.FT.ST (see [BrainCenterFEC_FT_BG Basal Ganglia]) DBB=[BrainRegionFAM_FT_SEP_DBB Diagonal Band of Broca,FAM.FT.SEP.DBB] DR=[BrainRegionLMC_MM_RP_DRN Dorsal Raphe Nucleus,LMC.MM.RP.DRN] GPi=Globus Pallidus Internal,FEC.FT.GPI (see [BrainCenterFEC_FT_BG Basal Ganglia]) IP=[BrainRegionFEC_HT_TG_IPD Interpeduncular Nucleus,FEC.HT.TG.IPD] LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (see [BrainCenterFD_HT Hypothalamus]) LHb=Lateral Habenula,FAM.FD.LHB (see [BrainCenterFAM_FD_HB Habenula]) LPO=[BrainRegionLAC_FD_HT_VLPO Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO] MHb=[BrainRegionFAM_FD_MHB Medial Habenula,FAM.FD.MHB] MR=[BrainRegionLMC_MM_RP_SUC Superior Central Raphe Nucleus,LMC.MM.RP.SUC] PB=[BrainRegionTARGET_TEA_ENDOCRINE Endocrine Glands,TARGET.TEA.ENDOCRINE] S=[BrainCenterFAM_FT_SEP Septal Nuclei,FAM.FT.SEP] SNc=[BrainRegionFEC_FT_SNC_LT Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT] VTA=[BrainRegionLMC_MM_VTA Ventral Tegmental Area,LMC.MM.VTA] unavailable = References = (generated) * http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full * http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html * http://www.scholarpedia.org/article/Habenula