#summary Habenula
@@[Home] -> [BiologicalLifeResearch] -> [BrainCenterFAM_FD_HB]
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This page covers biological details of component group Habenula.
Component group is part of aHuman target integrated biological model.

  * *Top-down path to center*: Forebrain Diencephalon -> Habenula (FAM.FD.HB) (see [OverallMindMaps Mind Maps])
  * *Function*: Encoding negative feedback
(generated)
= Components =
(generated)


*Component items*:
  * *Lateral Habenula* (FAM.FD.LHB): Encoding negative feedback, direct; motivational control of behavior; pain processing, reward, motivation, and learning
   * [BrainRegionFAM_FD_LHB_MED Lateral Habenula Medial Part] (FAM.FD.LHB.MED): Encoding negative feedback, direct, Septal
   * [BrainRegionFAM_FD_LHB_LT Lateral Habenula Lateral Part] (FAM.FD.LHB.LT): Encoding negative feedback, direct, Pallidal
  * [BrainRegionFAM_FD_MHB Medial Habenula] (FAM.FD.MHB): Encoding negative feedback, indirect

= Connectivity =
(generated)


*Internal Regions Connections:*

<img src="http://ahuman.org/svn/ahwiki/images/dot/CENTER.FAM.FD.HB_internals.dot.png" alt="unavailable" style="max-width: 100%;">


|| *Source Region* || *Target Region* || *Reference* ||
|| [BrainRegionFAM_FD_MHB Medial Habenula] (FAM.FD.MHB) || [BrainRegionFAM_FD_LHB_MED Lateral Habenula Medial Part] (FAM.FD.LHB.MED) || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (M -> L, abstract)] ||

*External Connections:*

<img src="http://ahuman.org/svn/ahwiki/images/dot/CENTER.FAM.FD.HB_externals.dot.png" alt="unavailable" style="max-width: 100%;">

*External Inbound Center Connections:*

|| *Source Center* || *Sample Link* || *Reference* ||
|| [BrainCenterFAM_FT_CEAM Central Extended Amygdala] (FAM.FT.CEAM) || [BrainRegionFAM_FT_EPF FAM.FT.EPF] -> [BrainRegionFAM_FD_LHB_LT FAM.FD.LHB.LT]||[http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full Regulation of the rapid eye movement (REM) sleep by habenular projection (EPN -> LHbL)] ||
|| [BrainCenterFAM_FT_SEP Septal Nuclei] (FAM.FT.SEP) || [BrainRegionFAM_FT_SEP_LT FAM.FT.SEP.LT] -> [BrainRegionFAM_FD_LHB_MED FAM.FD.LHB.MED]||[http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LS -> LHbM)] ||
|| [BrainCenterFD_HT Hypothalamus] (FD.HT) || [BrainRegionLAC_FD_HT_VLPO LAC.FD.HT.VLPO] -> [BrainRegionFAM_FD_LHB_LT FAM.FD.LHB.LT]||[http://www.scholarpedia.org/article/Habenula Habenula Connections (LPO -> LHb, abstract)] ||
|| [BrainCenterFEC_FT_BG Basal Ganglia] (FEC.FT.BG) || [BrainRegionFEC_FT_GPI_DS FEC.FT.GPI.DS] -> [BrainRegionFAM_FD_LHB_LT FAM.FD.LHB.LT]||[http://www.scholarpedia.org/article/Habenula Habenula Connections (GPi -> LHb, abstract)] ||
|| [BrainRegionLMC_HT_LC Locus Coeruleus] (LMC.HT.LC) || [BrainRegionLMC_HT_LC LMC.HT.LC] -> [BrainRegionFAM_FD_LHB_LT FAM.FD.LHB.LT]||[http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)] ||

*External Outbound Center Connections:*

|| *Target Center* || *Sample Link* || *Reference* ||
|| [BrainCenterFEC_FT_BG Basal Ganglia] (FEC.FT.BG) || [BrainRegionFAM_FD_LHB_MED FAM.FD.LHB.MED] -> [BrainRegionFEC_FT_SNC_LT FEC.FT.SNC.LT]||[http://www.scholarpedia.org/article/Habenula Habenula Connections (LHb -> SNc, abstract)] ||
|| [BrainCenterHL_RF Medullary Reticular Formation] (HL.RF) || [BrainRegionFAM_FD_LHB_MED FAM.FD.LHB.MED] -> [BrainRegionLMC_HL_RP_MG LMC.HL.RP.MG]||[http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)] ||
|| [BrainCenterHT_TG Pontine Tegmental Nuclei] (HT.TG) || [BrainRegionFAM_FD_LHB_LT FAM.FD.LHB.LT] -> [BrainRegionFEC_HT_TG_RMTG FEC.HT.TG.RMTG]||[http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbL -> RMTg)] ||
|| [BrainRegionLMC_MM_VTA Ventral Tegmental Area] (LMC.MM.VTA) || [BrainRegionFAM_FD_LHB_MED FAM.FD.LHB.MED] -> [BrainRegionLMC_MM_VTA LMC.MM.VTA]||[http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA)] ||
|| [BrainCenterMM_RF Mesencephalic Reticular Formation] (MM.RF) || [BrainRegionFAM_FD_LHB_MED FAM.FD.LHB.MED] -> [BrainRegionLMC_MM_RP_DRN LMC.MM.RP.DRN]||[http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)] ||
|| [BrainRegionTARGET_TEA_ENDOCRINE Endocrine Glands] (TARGET.TEA.ENDOCRINE) || [BrainRegionFAM_FD_MHB FAM.FD.MHB] -> [BrainRegionTARGET_TEA_ENDOCRINE TARGET.TEA.ENDOCRINE]||[http://www.scholarpedia.org/article/Habenula Habenula Connections (MHb -> PB)] ||